Journal Article

Association of chromosome 12p genetic polymorphisms with lung adenocarcinoma risk and prognosis.

G Manenti, L De Gregorio, S Pilotti, F S Falvella, M Incarbone, F Ravagnani, M A Pierotti and T A Dragani

in Carcinogenesis

Volume 18, issue 10, pages 1917-1920
Published in print October 1997 | ISSN: 0143-3334
Published online October 1997 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/18.10.1917
Association of chromosome 12p genetic polymorphisms with lung adenocarcinoma risk and prognosis.

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The mapping near Kras2 of pulmonary adenoma susceptibility 1 (Pas1), a major locus affecting inherited predisposition to lung cancer in mice prompted us to test the homologous human region (12p12) for association with lung adenocarcinoma, by a population-based study. We genotyped 213 lung adenocarcinoma patients and 219 healthy blood donor subjects for five polymorphic markers mapping in the putative region of interest. Three marker polymorphisms, located in a region spanning approximately 700 kb, were significantly associated with lung adenocarcinoma risk. Furthermore, polymorphisms in KRAS2 and PTHLH loci were also associated with tumor prognosis. These results suggest the existence of a human Pas1 homologous locus on chromosome 12p12.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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