Journal Article

p53-dependent response in UV-induced transformation.

W Zhang, X Zhang, H Zhu and S Chen

in Carcinogenesis

Volume 18, issue 12, pages 2319-2325
Published in print December 1997 | ISSN: 0143-3334
Published online December 1997 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/18.12.2319
p53-dependent response in UV-induced transformation.

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Cells carrying different numbers of copies of wild-type p53 were transformed by UV irradiation. Putative dense foci were analyzed for their growth behavior in low serum and for anchorage-independence. A correlation was found between number of copies of wild-type p53 gene and transformation frequency: cells with more copies of p53 gene were more resistant to transformation by UV. The p53 in the transformed clones was shown to be wild-type at the protein level. A single DNA base change was detected between GenBank data and our normal and transformed cells; this pre-existing single base difference is probably due to the differences between the strains of mice from which the cells were derived.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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