Journal Article

Regeneration versus neoplastic growth.

R T Prehn

in Carcinogenesis

Volume 18, issue 8, pages 1439-1444
Published in print August 1997 | ISSN: 0143-3334
Published online August 1997 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/18.8.1439
Regeneration versus neoplastic growth.

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Amphibian tissues seem to resist oncogenesis in proportion to their regenerative capacity, a phenomenon most easily seen in relation to limb regeneration. There is evidence that mammalian tissues also possess, in addition to and distinct from the capacity for physiological renewal, a limited and not always overtly evident degree of amphibian-like capacity for regeneration (epimorphic regeneration). It is the thesis of this paper that cancer in mammals would seldom occur were it not for a local destruction or exhaustion, secondary to injury or aging, of this normal amphibian-like regenerative capacity.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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