Journal Article

Adaptive response of human melanoma cells to methylglyoxal injury.

F Amicarelli, T Bucciarelli, A Poma, P Aimola, C Di Ilio, A M Ragnelli and M Miranda

in Carcinogenesis

Volume 19, issue 3, pages 519-523
Published in print March 1998 | ISSN: 0143-3334
Published online March 1998 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/19.3.519
Adaptive response of human melanoma cells to methylglyoxal injury.

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The effects of methylglyoxal on the growth of a line of human melanoma cells are investigated. Methylglyoxal inhibits cell growth in a dose-dependent manner and causes an increase in glyceraldehyde 3-phosphate dehydrogenase, and glyoxalase 1 and glyoxalase 2 specific activities. The cellular response to increasing concentrations of methylglyoxal in the culture medium is also studied by measuring L-lactate production, reduced-oxidized glutathione levels and apoptotic cell death. Methylglyoxal seems to promote a change of cell population phenotypic repertoire toward a more monomorphic phenotype. In conclusion, methylglyoxal seems to induce an enzymatic cellular response that lowers methylglyoxal levels and selects the most resistant cells.

Journal Article.  0 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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