Journal Article

Effects of smoking and aging on oxidative DNA damage of human lymphocytes.

S M Piperakis, E E Visvardis, M Sagnou and A M Tassiou

in Carcinogenesis

Volume 19, issue 4, pages 695-698
Published in print April 1998 | ISSN: 0143-3334
Published online April 1998 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/19.4.695
Effects of smoking and aging on oxidative DNA damage of human lymphocytes.

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The effects of H2O2-induced oxidative DNA damage in 80 healthy individuals with relation to age (20-25 and 55-60 years old) and smoking has been investigated with the comet assay technique. Both factors have shown a significant effect upon basal DNA damage with smoking appearing to have the most impact. A differentiation of the four groups response to induced oxidative damage was also observed. A distinctly separate behavior of the younger non-smokers group, when compared with the rest of the categories, was found. This is attributed to the lower degree of initial basal damage that occurs in their lymphocytes.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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