Journal Article

Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines.

C S Drugan, I C Paterson and S S Prime

in Carcinogenesis

Volume 19, issue 6, pages 1153-1156
Published in print June 1998 | ISSN: 0143-3334
Published online June 1998 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/19.6.1153
Fibroblast growth factor receptor expression reflects cellular differentiation in human oral squamous carcinoma cell lines.

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This study examined the expression of fibroblast growth factor receptor 2 (FGFR 2) splice variants, IIIb and IIIc, in normal and malignant human oral keratinocytes and in normal oral fibroblasts by RT-PCR using both exon-specific primers and primers common to both FGFR 2 isoforms. Fibroblasts expressed exclusively FGFR 2/IIIc whilst the normal and malignant keratinocytes co-expressed FGFR 2/IIIb and FGFR 2/IIIc. Well-differentiated keratinocytes expressed proportionally more FGFR 2/IIIb than IIIc whereas the poorly-differentiated cells expressed more FGFR 2/IIIc than IIIb. The normal and malignant keratinocytes, but not fibroblasts, expressed an additional amplification product, which consisted of both IIIb and IIIc of FGFR 2 joined by an extra base pair and with the intronic sequence removed. The results indicate that the expression of FGFR 2 isoforms reflects the degree of cellular differentiation in normal and malignant human oral keratinocytes and that receptor complexes of FGFR 2/IIIb and IIIc may regulate ligand-receptor interactions.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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