Journal Article

H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo.

S W Lee, C L Reimer, D B Campbell, P Cheresh, R B Duda and O Kocher

in Carcinogenesis

Volume 19, issue 6, pages 1157-1159
Published in print June 1998 | ISSN: 0143-3334
Published online June 1998 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/19.6.1157
H-cadherin expression inhibits in vitro invasiveness and tumor formation in vivo.

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H-cadherin is a newly characterized cadherin molecule whose expression is decreased in a variety of human carcinoma cells, suggesting that it may play a role in maintaining normal cellular phenotype. To investigate how re-expression of H-cadherin could influence the malignant phenotype of human breast carcinoma cells in vivo, we transfected both control and H-cadherin expression vectors into human breast cancer cells (MDAMB435), which do not express H-cadherin constitutively. We found that invasiveness of these cells could be prevented by transfection with H-cadherin. We also compared the ability of control- and H-cadherin-transfected cells to induce subcutaneous tumors after injection into mammary fat pads of nude mice. Our results show that H-cadherin transfection produced a marked inhibition of tumor growth and modified the morphology of tumor cells: tumors from mice injected with control cells were significantly larger and contained larger cells having a higher degree of pleomorphism than those of tumors generated from carcinoma cells expressing H-cadherin. Altogether, these results indicate that H-cadherin expression antagonizes tumor growth in nude mice, presumably by enhancing cell-cell association in a tissue environment. These findings strongly suggest that H-cadherin could provide a possible target for corrective gene therapy against breast cancer.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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