Journal Article

Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas.

J Mattern, R Koomägi and M Volm

in Carcinogenesis

Volume 19, issue 7, pages 1247-1250
Published in print July 1998 | ISSN: 0143-3334
Published online July 1998 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/19.7.1247
Smoking-related increase of O6-methylguanine-DNA methyltransferase expression in human lung carcinomas.

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Eighty-three non-small cell lung carcinomas (NSCLC) of previously untreated patients were analysed for expression of O6-methylguanine-DNA methyltransferase (MGMT) by means of immunohistochemistry. Expression of MGMT was detected in 62 of 83 tumours (75%). There was a significant difference in MGMT staining between smokers and non-smokers (P = 0.001). Tumours of smokers expressed more frequently MGMT than tumours of non-smokers. There was a trend of MGMT expression to be higher in tumours of patients smoking >20 cigarettes/day than patients smoking <20 cigarettes/day. Abstinence from smoking resulted in a significant decrease in MGMT expression (lin reg r = -0.59, P < 0.05). These results demonstrate that MGMT expression in human lung carcinomas is influenced by smoking habits of the patients.

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Subjects: Clinical Cytogenetics and Molecular Genetics

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