Journal Article

Induction of AP-1 activity by perillyl alcohol in breast cancer cells

Yoshiko Satomi, Shigeki Miyamoto and Michael N. Gould

in Carcinogenesis

Volume 20, issue 10, pages 1957-1961
Published in print October 1999 | ISSN: 0143-3334
Published online October 1999 | e-ISSN: 1460-2180 | DOI:
Induction of AP-1 activity by perillyl alcohol in breast cancer cells

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Monoterpenes display chemopreventive and therapeutic activity in rat mammary tumor models. Monoterpenes can also inhibit cell growth and induce apoptosis of cultured cells. In this study, the monoterpene perillyl alcohol (POH) was found to induce transient expression of the c-jun and c-fos genes transcriptionally. POH also transiently induced phosphorylation of c-Jun protein. These events were associated with transcriptional activation of an AP-1-dependent reporter gene. These results suggest that POH might affect c-Jun activity via the Jun N-terminal kinase/stress-activated protein kinase pathway and modulate expression of AP-1 target genes.

Keywords: ACD, actinomycin D; AP-1, activator protein 1; CHX, cycloheximide; JNK, Jun N-terminal kinase; M6P/IGF2R, mannose 6-phosphate/insulin-like growth factor 2 receptor; PBS, phosphate-buffered saline; POH, perillyl alcohol; TGFβ1, transforming growth factor β1; TNFα, tumor necrosis factor α; TPA, 12-O-tetradecanoylphorbol-13-acetate.

Journal Article.  3946 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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