Journal Article

Studies on the mechanism of cancer protection by wheat bran: effects on the absorption, metabolism and excretion of the food carcinogen 2-amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ)

Philip Kestell, Liangli Zhao, Shuotun Zhu, Philip J. Harris and Lynnette R. Ferguson

in Carcinogenesis

Volume 20, issue 12, pages 2253-2260
Published in print December 1999 | ISSN: 0143-3334
Published online December 1999 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/20.12.2253
Studies on the mechanism of cancer protection by wheat bran: effects on the absorption, metabolism and excretion of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)

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We examined ways in which dietary supplements of wheat bran may protect against colon cancer. The effects of supplementing the diet of female Wistar rats with 10% wheat bran on the disposition and metabolism of the dietary carcinogen 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ) labelled with 14C was determined. Our data show that the wheat bran had a major effect on both the distribution and metabolism of IQ. At a low dose of IQ (1 mg/kg), we unexpectedly found that up to 2 h after gavage there were higher concentrations of radioactivity in the plasma of rats fed wheat bran compared with the controls, but there were lower concentrations of radioactivity after 2 h. At a high dose of IQ (50 mg/kg), there were always lower concentrations of radioactivity in the plasma of rats fed wheat bran compared with the control rats. One of the most marked effects of wheat bran was apparently to significantly retard the metabolism of IQ in the plasma when this was fed at either dose. There were also differences between the rats fed wheat bran and the control in the concentrations and types of IQ metabolites in the urine.

Keywords: IQ, 2-amino-3-methylimidazo[4,5-f]quinoline; IQ-N-sulphamate, N-(3-methylimidazo[4,5-f]quinolin-2-yl)sulphamic acid; IQ-5-O-glucuronide, 2-amino-5-(glucosiduronyloxy)-3-methylimidazo[4,5-f]quinoline; IQ-5-O-sulphate, 2-amino-3-methylimidazo[4,5-f]quinolin-5-yl sulphate.

Journal Article.  6205 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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