Journal Article

Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

Chuanshu Huang, Wei-ya Ma, Angela Goranson and Zigang Dong

in Carcinogenesis

Volume 20, issue 2, pages 237-242
Published in print February 1999 | ISSN: 0143-3334
Published online February 1999 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/20.2.237
Resveratrol suppresses cell transformation and induces apoptosis through a p53-dependent pathway

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Resveratrol, a plant constituent enriched in the skin of grapes, is one of the most promising agents for the prevention of cancer. However, the mechanism of the anti-carcinogenic activity of resveratrol is not well understood. Here we offer a possible explanation of its anti-cancer effect. Resveratrol suppresses tumor promoter-induced cell transformation and markedly induces apoptosis, transactivation of p53 activity and expression of p53 protein in the same cell line and at the same dosage. Also, resveratrol-induced apoptosis occurs only in cells expressing wild-type p53 (p53+/+), but not in p53-deficient (p53–/–) cells, while there is no difference in apoptosis induction between normal lymphoblasts and sphingomyelinase-deficient cell lines. These results demonstrate for the first time that resveratrol induces apoptosis through activation of p53 activity, suggesting that its anti-tumor activity may occur through the induction of apoptosis.

Keywords: BME, basal medium Eagle; DMEM, Dulbecco's modified Eagle's medium; DMSO, dimethyl sulfoxide; EBV, Epstein–Barr virus; EGF, epidermal growth factor; FBS, fetal bovine serum; MEM, Eagle's minimal essential medium; SMase, sphingomyelinase; TPA, 12-O-tetradecanoylphorbol-13-acetate.

Journal Article.  3572 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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