Journal Article

Frameshift mutations in <i>TGFβRII</i>, <i>IGFIIR</i>, <i>BAX</i>, <i>hMSH3</i> and <i>hMSH6</i> are absent in lung cancers

Kunihiko Gotoh, Yasushi Yatabe, Takahiko Sugiura, Kenzo Takagi, Makoto Ogawa, Takashi Takahashi and Tetsuya Mitsudomi

in Carcinogenesis

Volume 20, issue 3, pages 499-502
Published in print March 1999 | ISSN: 0143-3334
Published online March 1999 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/20.3.499
Frameshift mutations in TGFβRII, IGFIIR, BAX, hMSH3 and hMSH6 are absent in lung cancers

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A genome-wide instability at simple repeat sequences characterizes gastrointestinal and endometrial cancers of the microsatellite mutator phenotype (MMP). The genes encoding transforming growth factor-β receptor type II (TGFβRII), insulin-like growth factor II receptor (IGFIIR), Bcl-2 associated X protein (BAX), hMSH3 and hMSH6 have simple repeat sequences in their coding regions. Consequently, mutations in the single repeat sequences in these genes provide one major route for carcinogenesis in these cancers. We examined 43 non-small cell lung carcinomas and 16 small cell carcinomas for frameshift mutations in simple repeat sequences of TGFβRII, IGFIIR, BAX, hMSH3 and hMSH6. In addition, MMP was assessed using a primer set for BAT-26. None of 59 lung cancers exhibited frameshift mutations or MMP. It is concluded that somatic frameshift mutations in these genes and MMP do not constitute important mechanisms in lung carcinogenesis. The possibility of some sort of genetic instability undetectable as a form of MMP cannot be precluded.

Keywords: BAX, Bcl-2-associated X protein; HNPCC, hereditary non-polyposis colorectal cancer; IGFIIR, insulin-like growth factor II receptor gene; MMP, microsatellite mutator phenotype; NSCLC, non-small cell lung cancer; SCLC, small cell lung cancers; TGFβRII, transforming growth factor-β receptor type II gene.

Journal Article.  2808 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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