Journal Article

Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid

Sebastiano Banni, Elisabetta Angioni, Viviana Casu, Maria Paola Melis, Gianfranca Carta, Francesco P. Corongiu, Henry Thompson and Clement Ip

in Carcinogenesis

Volume 20, issue 6, pages 1019-1024
Published in print June 1999 | ISSN: 0143-3334
Published online June 1999 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/20.6.1019
Decrease in linoleic acid metabolites as a potential mechanism in cancer risk reduction by conjugated linoleic acid

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Previous research suggested that conjugated linoleic acid (CLA) feeding during the period of pubescent mammary gland development in the rat resulted in diminished mammary epithelial branching which might account for the reduction in mammary cancer risk. Terminal end buds (TEB) are the primary sites for the chemical induction of mammary carcinomas in rodents. One of the objectives of the present study was to investigate the modulation of TEB density by increasing levels of dietary CLA and to determine how this might affect the risk of methylnitrosourea-induced mammary carcinogenesis. The data show a graded and parallel reduction in TEB density and mammary tumor yield produced by 0.5 and 1% CLA. No further decrease in either parameter was observed when CLA in the diet was raised to 1.5 or 2%. Thus, optimal CLA nutrition during pubescence could conceivably control the population of cancer-sensitive target sites in the mammary gland. Since both CLA and linoleic acid are likely to share the same enzyme system for chain desaturation and elongation, it is possible that increased CLA intake may interfere with the further metabolism of linoleic acid. Fatty acid analysis of total lipid showed that CLA and CLA metabolites continued to accumulate in mammary tissue in a dose-dependent manner over the range 0.5–2% CLA. There was no perturbation in tissue linoleic acid, however, linoleic acid metabolites (including 18:3, 20:3 and 20:4) were consistently depressed by up to 1% CLA. Of particular interest was the significant drop in 20:4 (arachidonic acid), which is the substrate for the cyclooxygenase and lipoxygenase pathways of eicosanoid biosynthesis. Thus the CLA dose–response effect on arachidonic acid suppression corresponded closely with the CLA dose–response effect on cancer protection in the mammary gland. This information is critical in providing new insights regarding the biochemical action of CLA.

Keywords: CD, conjugated diene; CLA, conjugated linoleic acid; MNU, methylnitrosourea; TEB, terminal end bud.

Journal Article.  5299 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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