Journal Article

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats

Min Wei, Hideki Wanibuchi, Shinji Yamamoto, Wei Li and Shoji Fukushima

in Carcinogenesis

Volume 20, issue 9, pages 1873-1876
Published in print September 1999 | ISSN: 0143-3334
Published online September 1999 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/20.9.1873
Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats

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The present study was conducted to determine the carcinogenicity of dimethylarsinic acid (DMA) administered to male F344 rats in a 2 year bioassay. A total of 144 rats (10 weeks old at the start) were divided into four groups of 36 rats each. Groups 1–4 received DMA (purity 100%) at concentrations of 200, 50, 12.5 and 0 p.p.m. in the drinking water, respectively, for 104 weeks. From weeks 97 to 104, urinary bladder tumors were observed in 12 of 31, eight of 31 and none of 33 in groups 1–3, respectively. No bladder tumors were observed in group 4. The present study demonstrated that long-term p.o. administration of DMA induced urinary bladder carcinomas in male F344 rats. Therefore, the results indicate that DMA is carcinogenic for the rat urinary bladder, which may be related to the human carcinogenicity of arsenicals.

Keywords: DMA, dimethylarsenic acid; TCC, transitional cell carcinoma.

Journal Article.  3569 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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