Journal Article

Chemoprevention of cancer

Michael B. Sporn and Nanjoo Suh

in Carcinogenesis

Volume 21, issue 3, pages 525-530
Published in print March 2000 | ISSN: 0143-3334
Published online March 2000 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/21.3.525
Chemoprevention of cancer

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In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemopreventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor modulators, rexinoids (retinoids that bind selectively to the receptors known as RXRs) and ligands for the peroxisome proliferator-activated receptor-γ are discussed in detail. The importance of developing totally new classes of chemopreventive agents is stressed, with particular emphasis on the potential usefulness of new synthetic triterpenoids derived from naturally occurring molecules.

Keywords: COX, cyclooxygenase; PPAR-γ, peroxisome proliferator-activated receptor-γ; RAR, retinoic acid receptor; RXR, retinoid X receptor; SERM, selective estrogen receptor modulator.

Journal Article.  4879 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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