Journal Article

The <i>INK4a/ARF</i> locus in murine tumorigenesis

Manuel Serrano

in Carcinogenesis

Volume 21, issue 5, pages 865-869
Published in print May 2000 | ISSN: 0143-3334
Published online May 2000 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/21.5.865
The INK4a/ARF locus in murine tumorigenesis

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The INK4a/ARF locus is regarded as one of the most important anti-tumoral defenses that mammalian organisms possess. The characterization of its two gene products, p16INK4a and p19ARF, has provided a great insight on the functioning of the tumor suppressors Rb and p53, respectively. Present evidence indicates that the INK4a/ARF locus is transcriptionally activated by oncogenic stresses, resulting in cell-cycle arrest or apoptosis. Here, I review the evidence accumulated on the involvement of the INK4a/ARF locus in murine tumorigenesis. Also, I summarize the phenotype of the different transgenic mouse models based on the inactivation of the INK4a/ARF locus.

Journal Article.  4544 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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