Journal Article

Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells

Raheel M. Ansari and Tom K. Hei

in Carcinogenesis

Volume 21, issue 6, pages 1221-1226
Published in print June 2000 | ISSN: 0143-3334
Published online June 2000 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/21.6.1221
Effects of 60 Hz extremely low frequency magnetic fields (EMF) on radiation- and chemical-induced mutagenesis in mammalian cells

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

There is considerable uncertainty of the potential biological effects of extremely low frequency magnetic fields (ELF-MF or EMF) because of mixed results in epidemiological and laboratory studies. In the present study, exponentially growing human–hamster hybrid AL cells were treated with a 100 μT alternating EMF powered at 60 Hz for either 24 h or 7 days. Exposure to EMF was conducted either alone or in combination with graded doses of a physical or chemical carcinogen. γ-radiation was chosen as a form of ionizing radiation while N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) was chosen as a form of chemical contaminant. Exposure of AL cells to EMF alone for a period up to 7 days was non-cytotoxic and non-mutagenic. Concurrent EMF treatment did not increase either the cytotoxicity or induction of CD59– mutants by graded doses of γ-rays or MNNG in AL cells. This study shows conclusively that short-term or long-term exposure to EMF alone neither affects the survival of AL cells nor increases the mutagenic potency of other environmental carcinogens.

Keywords: ELF-MF (or EMF), extremely low frequency magnetic fields; MNNG, N-methyl-N′-nitro-N-nitrosoguanidine.

Journal Article.  4835 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.