Journal Article

Mice deficient in the nucleotide excision repair gene <i>XPA</i> have elevated sensitivity to benzo[<i>a</i>]pyrene induction of lung tumors

Fumio Ide, Naoko Iida, Yoko Nakatsuru, Hideaki Oda, Kiyoji Tanaka and Takatoshi Ishikawa

in Carcinogenesis

Volume 21, issue 6, pages 1263-1265
Published in print June 2000 | ISSN: 0143-3334
Published online June 2000 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/21.6.1263
Mice deficient in the nucleotide excision repair gene XPA have elevated sensitivity to benzo[a]pyrene induction of lung tumors

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This study is focused on chemical induction of lung tumors in xeroderma pigmentosum group A gene (XPA)-deficient mice to clarify the role of nucleotide excision repair (NER) in internal organs. Six-week-old female XPA–/–, XPA+/– and XPA+/+ mice were instilled intratracheally with benzo[a] pyrene (B[a]P). A total of 68 surviving XPA mice treated with B[a]P were examined at month 16. The pulmonary adenoma incidence in XPA–/– mice was significantly higher than that in XPA+/+ mice (71 versus 35%). Similarly, tumor multiplicity was elevated and, in addition, only XPA–/– mice had lung carcinomas. These results provide the first evidence that a deficiency in the NER gene XPA leads to enhanced tumorigenesis in the lung after exposure to B[a]P.

Keywords: B[a]P, benzo[a]pyrene; NER, nucleotide excision repair; XP, xeroderma pigmentosum; XPA, XP group A.

Journal Article.  2118 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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