Journal Article

A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice

H.L. Newmark, K. Yang, M. Lipkin, L. Kopelovich, Y. Liu, K. Fan and H. Shinozaki

in Carcinogenesis

Volume 22, issue 11, pages 1871-1875
Published in print November 2001 | ISSN: 0143-3334
Published online November 2001 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/22.11.1871
A Western-style diet induces benign and malignant neoplasms in the colon of normal C57Bl/6 mice

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Decreased dietary intakes of calcium, vitamin D and folic acid have been suggested as risk factors for human colon cancer. We previously fed a Western-style diet (WD) containing reduced calcium, vitamin D and increased fat content to normal C57/Bl6 mice: hyperproliferation, hyperplasia and whole crypt dysplasias developed in the colon following WD administration. Utilizing the same diet, we now also decreased the levels of several nutrients that are required for biochemical reactions involving methyl group inadequacy, i.e. folic acid, methionine, choline and vitamin B12. Dietary levels of these nutrients were reduced to nutrient-density levels approximating those consumed by large segments of human Western populations. This further modification of the WD resulted in adenoma and carcinoma development in normal mouse colon (P < 0.04 compared with AIN-76A diet). The results indicate, for the first time, that a semi-purified rodent diet designed to mimic the human Western diet can induce colonic tumors in normal mice without carcinogen exposure.

Keywords: Apc, adenomatous polyposis coli; kcal, kilocalories; NWD, new Western-style diet; WD, Western-style diet

Journal Article.  5428 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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