Journal Article

HMGI-C gene expression is not required for <i>in vivo</i> thyroid cell transformation

Stefania Scala, Giuseppe Portella, Donatella Vitagliano, Catherine Ledent, Gennaro Chiappetta, Vincenzo Giancotti, Jacques Dumont and Alfredo Fusco

in Carcinogenesis

Volume 22, issue 2, pages 251-256
Published in print February 2001 | ISSN: 0143-3334
Published online February 2001 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/22.2.251
HMGI-C gene expression is not required for in vivo thyroid cell transformation

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We have previously demonstrated that HMGI proteins are required for the transformation of rat thyroid cells by v-mos and v-ras-Ki oncogenes. To determine whether HMGI proteins are also required for in vivo thyroid carcinogenesis, mice carrying a disrupted HMGI-C gene (pygmy mice) were either treated with radioactive iodine or crossed with transgenic mice carrying the E7 papilloma virus oncogene under the transcriptional control of thyroglobulin gene promoter. The pygmy mice developed thyroid carcinomas with the same frequency as occurred in wild-type mice without significant macroscopic and microscopic differences. Therefore, these results indicate that HMGI-C gene expression is not required in in vivo thyroid cell malignant transformation.

Journal Article.  3838 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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