Journal Article

Curcumin modifies Apc<sup>min</sup> apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apc<sup>min</sup> mice

Gavin Patrick Collett, Craig Nigel Robson, John Cummings Mathers and Frederick Charles Campbell

in Carcinogenesis

Volume 22, issue 5, pages 821-825
Published in print May 2001 | ISSN: 0143-3334
Published online May 2001 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/22.5.821
Curcumin modifies Apcmin apoptosis resistance and inhibits 2-amino 1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) induced tumour formation in Apcmin mice

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Curcumin, the active ingredient of the rhizome of Curcuma longa, promotes apoptosis and may have chemopreventive properties. This study investigates the effects of curcumin on apoptosis and tumorigenesis in male Apcmin mice treated with the human dietary carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Intestinal epithelial apoptotic index in response to PhIP treatment was approximately twice as great in the wild-type C57BL/6 APC+/+ strain than in Apcmin mice (3.7% Apc+/+ versus 1.9% Apcmin ; P < 0.001). PhIP promoted tumour formation in Apcmin proximal small intestine (4.6 tumours per mouse, PhIP treated versus 2.1 tumours per mouse, control untreated; P < 0.05). Curcumin enhanced PhIP-induced apoptosis (4.0% curcumin + PhIP versus 2.1% PhIP alone; P < 0.01) and inhibited PhIP-induced tumorigenesis in the proximal small intestine of Apcmin mice (2.2 tumours per mouse, curcumin + PhIP versus 4.6 tumours per mouse PhIP alone; P < 0.05). This study shows that the Apcmin genotype is associated with resistance to PhIP-induced apoptosis in intestinal epithelium. Curcumin attenuates Apcmin resistance to PhIP-induced apoptosis and inhibits PhIP-induced tumorigenesis in proximal Apcmin mouse small intestine.

Keywords: APC, adenomatous polyposis coli; FAP, familial adenomatous polyposis; HCA, heterocyclic amines; ISEL, in situ end-labelling; NF κB, nuclear factor kappa B; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; TNFα, tumour necrosis factor alpha.

Journal Article.  3767 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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