Journal Article

Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk

Katja Mitrunen, Pia Sillanpää, Vesa Kataja, Matti Eskelinen, Veli-Matti Kosma, Simone Benhamou, Matti Uusitupa and Ari Hirvonen

in Carcinogenesis

Volume 22, issue 5, pages 827-829
Published in print May 2001 | ISSN: 0143-3334
Published online May 2001 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/22.5.827
Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk

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Superoxide dismutases play a key role in the detoxification of superoxide radicals and thus protect cells from damage induced by free radicals. Within mitochondria manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species. Polymorphism in the mitochondrial targeting sequence of MnSOD has recently been associated with risk of breast cancer. We examined this in a study population consisting of 483 breast cancer cases and 482 controls, all of Finnish Caucasian origin. Odds ratios (OR) and 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression. MnSOD genotypes containing the variant A allele were found to be associated with a 1.5-fold (95% CI 1.1–2.0) increased risk of breast cancer compared with those with the homozygous wild-type genotype (MnSOD VV). This finding supports the proposal that MnSOD genotypes may modify individual breast cancer risk.

Keywords: MnSOD, manganese superoxide dismutase; MTS, mitochondrial targeting sequence; OR, odds ratio; RFLP, restriction fragment length polymorphism; ROS, reactive oxygen species.

Journal Article.  2708 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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