Journal Article

A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol

Julie Gusman, Hugues Malonne and Ghanem Atassi

in Carcinogenesis

Volume 22, issue 8, pages 1111-1117
Published in print August 2001 | ISSN: 0143-3334
Published online August 2001 | e-ISSN: 1460-2180 | DOI:
A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol

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Resveratrol, a phytoalexin found in grapes and wines, has been reported to exhibit a wide range of pharmacological properties and is believed to play a role in the prevention of human cardiovascular disease (the so-called `French paradox'). This molecule may also play a major role in both cancer prevention and therapy. In this review article we summarize the recent advances that have provided new insights into the molecular mechanisms underlying the promising properties of resveratrol. These include cyclooxygenase, nitric oxide synthase and cytochrome P450 inhibition, as well as cell cycle effects, apoptosis modulation and hormonal activity.

Keywords: ACF, aberrant crypt foci; AhR, aryl hydrocarbon receptor; AP-1, activator protein-1; COX, cyclooxygenase; DMBA, 7-12-dimethylbenzanthracene; ER, oestrogen receptor; eNOS, endothelial NOS; GJIC, gap-junctional intercellular communication; iNOS, inducible NOS; LPS, lipopolysaccharide; PGs, prostaglandins; PKC, protein kinase C; PMA, phorbol 12-myristate 13-acetate; PR, progesterone receptor; PSA, prostate-specific antigen; TGF, transforming growth factor; TNF, tumour necrosis factor; TPA, 12-O-tetradecanoylphorbol-13-acetate.

Journal Article.  6705 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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