Journal Article

Migrating colonic crypt epithelial cells: primary targets for transformation

Sergio A. Lamprecht and Martin Lipkin

in Carcinogenesis

Volume 23, issue 11, pages 1777-1780
Published in print November 2002 | ISSN: 0143-3334
Published online November 2002 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/23.11.1777
Migrating colonic crypt epithelial cells: primary targets for transformation

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  • Clinical Cytogenetics and Molecular Genetics

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It is widely believed that stem cells are the relevant target cells for colonic cell transformation. Evidence is presented that a proliferative transit daughter cell acquiring a mutant adenomatous polyposis coli gene during upward migration from the crypt base can develop retention abnormalities and permanence in the crypt, thus qualifying as a transformed clone which is retained in the colonic epithelium.

Keywords: APC, adenomatous polyposis coli.

Journal Article.  3892 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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