Journal Article

<i>CYP2A6</i> gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

Zeki Topcu, Itsuo Chiba, Masaki Fujieda, Toshiyuki Shibata, Noritaka Ariyoshi, Hiroshi Yamazaki, Figen Sevgican, Malsantha Muthumala, Hiroshi Kobayashi and Tetsuya Kamataki

in Carcinogenesis

Volume 23, issue 4, pages 595-598
Published in print April 2002 | ISSN: 0143-3334
Published online April 2002 | e-ISSN: 1460-2180 | DOI:
CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

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  • Clinical Cytogenetics and Molecular Genetics


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We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was significantly lower in the case subjects than the controls. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.14 (95% CI; 0.03–0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers.

Keywords: BQ, betel quid; CYPs, cytochrome P450 enzymes; GSTM1, glutathione-S-transferase μ; class isozyme; PCR, polymerase chain reaction.

Journal Article.  2937 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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