Journal Article

Myeloid, B and T lymphoid and mixed lineage thymic lymphomas in the irradiated mouse

Emma Boulton, Helen Cleary and Mark Plumb

in Carcinogenesis

Volume 23, issue 6, pages 1079-1085
Published in print June 2002 | ISSN: 0143-3334
Published online June 2002 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/23.6.1079
Myeloid, B and T lymphoid and mixed lineage thymic lymphomas in the irradiated mouse

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Thymic lymphoma is a very common spontaneous and/or induced malignancy in both inbred mice and in transgenic mouse models of human cancer. Although a thymic lymphoma is defined as thymus-dependent T-cell malignancy, diagnostic criteria vary between studies and considerable heterogeneity has been reported. To define and classify the thymic lymphomas that arose in our study of X-irradiated (CBA/H×C57BL/6)F1, F1 backcross and F1 intercross mice, 66 thymic lymphomas were immunogenotyped for immunoglobulin heavy chain (IgH) and T-cell receptor β (TCRβ) gene rearrangements, and/or analysed for expression of lineage-specific markers and allelic loss on chromosome 4. The data indicate that 33% of the thymic lymphomas are very similar to mouse radiation-induced acute myeloid (AML) and mixed lineage (IgHR, TCRβG) pre-B lympho-myeloid (L-MLs) leukaemias, 33% are mixed lineage (IgHR, TCRβR) B/T lymphoid and <33% can be described as single lineage (IgHG, TCRβR) T-cell malignancies. As the myeloid and L-ML leukaemias are not thymus-dependent this suggests that a malignant myeloid or pre-B lympho-myeloid cell can colonize the spleen to give an AML or L-ML leukaemia, or can colonize the thymus where TCRβ gene rearrangement(s) may be induced to give the mixed lineage thymic lymphomas. Thus, assuming the single lineage T-cell thymic lymphomas fulfil the criteria of a thymus-dependent T-cell malignancy, thymic lymphomas are comprised of at least three distinct malignancies.

Keywords: AML, acute myeloid leukaemia; L-ML, pre-B lympho-myeloid leukaemias; LysM, lysozyme M; MPO, myeloperoxidase

Journal Article.  5992 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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