Journal Article

Toxicogenomics: the new frontier in risk analysis

P.Trinia Simmons and Christopher J. Portier

in Carcinogenesis

Volume 23, issue 6, pages 903-905
Published in print June 2002 | ISSN: 0143-3334
Published online June 2002 | e-ISSN: 1460-2180 | DOI:
Toxicogenomics: the new frontier in risk analysis

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  • Clinical Cytogenetics and Molecular Genetics


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Risk assessment involves the identification of potential human health hazards, the assessment of the level of exposure by humans to these hazards and the evaluation of the relationship between exposure and response in humans. Research is currently underway to improve the scientific basis of risk assessment through the incorporation of new technologies such as transgenic animals, molecular epidemiology, toxicogenomics, alternative models to animals and mechanism-based mathematical modeling into the estimation of risk in a quantitative manner. This paper briefly discusses these technologies and how each is being employed for more scientifically sound risk assessments.

Keywords: DCM, dichloromethane; PBPK, physiologically based pharmacokinetic modela

Journal Article.  2446 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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