Journal Article

The effect of β-carotene on lung and skin carcinogenesis

George Wolf

in Carcinogenesis

Volume 23, issue 8, pages 1263-1265
Published in print August 2002 | ISSN: 0143-3334
Published online August 2002 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/23.8.1263
The effect of β-carotene on lung and skin carcinogenesis

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The induction of pre-cancerous squamous metaplasia in lungs of ferrets by high doses of dietary β-carotene (BC) and cigarette smoke is compared with and contrasted to the different effects of high doses of dietary BC on skin papilloma and carcinoma induction by the two-stage carcinogenesis protocol. Whereas high dietary BC can inhibit the conversion of skin papillomas to carcinomas, such treatment would not be expected to inhibit smoke-induced lung tumors.

Keywords: BC, β-carotene; DMBA, 7,12-dimethylbenz[a]anthracene; RA, retinoic acid; TPA, 12-O-tetradecanoylphorbol-13-acetate

Journal Article.  2233 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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