Journal Article

DNA repair gene <i>XRCC1</i> and <i>XPD</i> polymorphisms and risk of lung cancer in a Chinese population

Senqing Chen, Deliang Tang, Kaixian Xue, Lin Xu, Guojian Ma, Yanzhi Hsu and Stanley S. Cho

in Carcinogenesis

Volume 23, issue 8, pages 1321-1325
Published in print August 2002 | ISSN: 0143-3334
Published online August 2002 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/23.8.1321
DNA repair gene XRCC1 and XPD polymorphisms and risk of lung cancer in a Chinese population

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X-ray repair cross-complementing group 1 (XRCC1) and xeroderma pigmentosum group D (XPD) are mainly involved in base excision repair (BER) and nucleotide excision repair (NER) of DNA repair pathways, respectively. Polymorphisms of DNA repair gene XRCC1 and XPD has recently been identified, and there is a growing body of evidence that these polymorphisms may have some phenotypic significance. To investigate the role of XRCC1 polymorphisms (codon 194 and codon 399) and XPD polymorphism (codon 751) in lung cancer, a population-based case-control study of 109 lung cancer patients and 109 healthy control subjects (individually matched on age and gender) in a Chinese population was conducted. XRCC1 and XPD genotypes were identified using PCR–restriction fragments length polymorphism technique. Conditional logistic regression analysis revealed that XRCC1 codon 194Trp/Trp genotype was associated with a borderline increased risk of lung cancer [adjusted odd ratio (OR) = 3.06; confidence interval (CI) 0.94–9.92]. The XPD 751 Lys allele (combined Lys/Lys and Lys/Gln genotypes) was associated with a significantly increased risk of lung cancer (OR = 3.19; CI 1.01–10.07). The risk of lung cancer increased more than additive interaction (adjusted OR = 8.77; CI 1.47–52.31) for the individuals with both putative high-risk genotypes of XRCC1 194 Trp/Trp and XPD 751 Lys allele. Our results suggested that the genotypes of XRCC1 194Trp/Trp and XPD 751 Lys allele might be the risk genotypes for lung cancer in Chinese population.

Keywords: BER, base excision repair; DRC, DNA repair capacity; NER, nucleotide excision repair; XPD, xeroderma pigmentosum group D; XRCC1, X-ray repair cross-complementing group 1

Journal Article.  4359 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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