Journal Article

Pre-cancerous lesions for colorectal cancers in rodents: a new concept

Yasuhiro Yamada and Hideki Mori

in Carcinogenesis

Volume 24, issue 6, pages 1015-1019
Published in print June 2003 | ISSN: 0143-3334
Published online June 2003 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgg041
Pre-cancerous lesions for colorectal cancers in rodents: a new concept

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It is widely believed that colorectal carcinogenesis is a representative multi-step tumorigenesis with events of genetic alterations. Aberrant crypt foci (ACF) recognized on the surface of cancer-predisposed colons of rodents have been regarded as early-appearing pre-neoplastic lesions. However, it is not clear if such lesions are truly pre-cancerous lesions for colorectal cancers in rodents. Recently, β-catenin-accumulated crypts (BCAC) were identified in colonic mucosa at the early stages of colon carcinogenesis. Accumulating evidence indicates that they are independent small dysplastic lesions of ACF. Here we discuss the importance of BCAC as pre-cancerous lesions in colon carcinogenesis.

Keywords: ACF, aberrant crypt foci; AOM, azoxymethane; APC, adenomatous polyposis coli; BCAC, β-catenin-accumulated crypts

Journal Article.  3874 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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