Journal Article

Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis

Vassilis Zoumpourlis, Sylvia Solakidi, Alexandra Papathoma and Dimitra Papaevangeliou

in Carcinogenesis

Volume 24, issue 7, pages 1159-1165
Published in print July 2003 | ISSN: 0143-3334
Published online July 2003 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgg067
Alterations in signal transduction pathways implicated in tumour progression during multistage mouse skin carcinogenesis

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The multistage mouse skin carcinogenesis model, although an artificial one, is an ideal system to study the timing of qualitative and quantitative alterations which take place during the different stages of chemical carcinogenesis, allowing analysis of the events that lead to the transition from the stage of initiation to the stage of promotion and finally to the progression of carcinogenesis. In this review we focus on the role of the H-ras gene and its target molecules during mouse skin carcinogenesis. Besides H-ras, which is a critical target of chemical carcinogens, we report alterations in oncosuppressor genes. Finally, we examine the potential suppression of metastatic dynamics of spindle cells after biological or chemical inhibition of the signalling cascades involved in mouse skin carcinogenesis.

Keywords: AP-1; activated protein-1; ARF, alternative reading fragment; cdk, cyclin-dependent kinase; CRE, c-AMP response elements; DMBA, 7,12-dimethylbenz[a]anthracene; MAPK, mitogen activated protein kinase; MMPs, matrix metalloproteinases; PIN, prostate intraepithelial neoplasia; SRF, serum response factor; TPA, 12-O-tetradecanoylphorbol-13-acetate; TRE, TPA response elements

Journal Article.  4969 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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