Journal Article

Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer

Hyo-Sung Jeon, Kyung Mee Kim, Sun Ha Park, Su Yeon Lee, Jin Eun Choi, Ga Young Lee, Sin Kam, Rang Woon Park, In-San Kim, Chang Ho Kim, Tae Hoon Jung and Jae Yong Park

in Carcinogenesis

Volume 24, issue 10, pages 1677-1681
Published in print October 2003 | ISSN: 0143-3334
Published online October 2003 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgg120
Relationship between XPG codon 1104 polymorphism and risk of primary lung cancer

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DNA repair plays a critical role in protecting the genome from insults of cancer-causing agents, such as those found in tobacco smoke. Therefore, reduced DNA repair capacity can increase the susceptibility to smoking-related cancers. Recently, several polymorphisms have been identified in the xeroderma pigmentosum group G (XPG) gene, and it is possible that these polymorphisms may affect the DNA repair capacity, thereby modulating cancer susceptibility. We investigated the relationship between the His1104Asp polymorphism in the XPG gene and the risk of lung cancer. The study population consisted of 310 lung cancer patients and 311 healthy controls who were frequency (1:1) matched based on age and sex. The Asp/Asp genotype was more frequent in the controls (28.9%) than in the cases (18.7%) and associated with a significantly decreased risk of lung cancer [adjusted odds ratio (OR) = 0.54, 95% confidence interval (CI) = 0.37–0.80] when the combined His/His and His/Asp genotype was used as the reference. The protective effect of the Asp/Asp genotype against lung cancer was statistically significant in the older subjects (adjusted OR = 0.51, 95% CI = 0.37–0.80), males (adjusted OR = 0.54, 95% CI = 0.35–0.83), and lighter smokers (adjusted OR = 0.48, 95% CI = 0.25–0.94) in a stratification analysis. When the lung cancers were analyzed by histologic type, the Asp/Asp genotype was associated with a significantly decreased risk of squamous cell carcinoma (adjusted OR = 0.55, 95% CI = 0.34–0.88) and small cell lung cancer (adjusted OR = 0.44, 95% CI = 0.20–0.97), but non-significant decreased risk of adenocarcinoma (adjusted OR = 0.64, 95% CI = 0.36–1.12). These results suggest that the XPG codon 1104 polymorphism contributes to genetic susceptibility to lung cancer.

Keywords: CI, confidence interval; NER, nucleotide excision repair; OR, odds ratio; XPG, xeroderma pigmentosum group G

Journal Article.  3695 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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