Journal Article

Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice

Manuela Gariboldi, Monica Spinola, Silvano Milani, Carmen Pignatiello, Koji Kadota, Hidemasa Bono, Yoshihide Hayashizaki, Tommaso A. Dragani and Yasushi Okazaki

in Carcinogenesis

Volume 24, issue 11, pages 1819-1826
Published in print November 2003 | ISSN: 0143-3334
Published online November 2003 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgg133
Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice

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Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.

Keywords: Pas1, pulmonary adenoma susceptibility 1

Journal Article.  4807 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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