Journal Article

p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis

Toshiyuki Habu, Nobunao Wakabayashi, Kayo Yoshida, Kenntaro Yomogida, Yoshitake Nishimune and Takashi Morita

in Carcinogenesis

Volume 25, issue 6, pages 889-893
Published in print June 2004 | ISSN: 0143-3334
Published online June 2004 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgh099
p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis

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The tumor suppressor protein p53 is specifically expressed during meiosis in spermatocytes. Subsets of p53 knockout mice exhibit testicular giant cell degenerative syndrome, which suggests p53 may be associated with meiotic cell cycle and/or DNA metabolism. Here, we show that p53 binds to the mouse meiosis-specific RecA-like protein Mus musculus DMC1 (MmDMC1). The C-terminal domain (amino acid 234–340) of MmDMC1 binds to DNA-binding domain of p53 protein. p53 might be involved in homologous recombination and/or checkpoint function by directly binding to DMC1 protein to repress genomic instability in meiotic germ cells.

Keywords: GST, glutathione S-transferase; MmDMC1, Mus musculus DMC1

Journal Article.  3225 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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