Journal Article

Curcumin impairs tumor suppressor p53 function in colon cancer cells

Philip J. Moos, Kornelia Edes, James E. Mullally and Frank A. Fitzpatrick

in Carcinogenesis

Volume 25, issue 9, pages 1611-1617
Published in print September 2004 | ISSN: 0143-3334
Published online September 2004 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgh163
Curcumin impairs tumor suppressor p53 function in colon cancer cells

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Curcumin (diferuloylmethane) is being considered as a potential chemopreventive agent in humans. In vitro it inhibits transcription by NF-κB, and the activity of lipoxygenase or cyclooxygenase enzymes, which facilitate tumor progression. In vivo it is protective in rodent models of chemical carcinogenesis. Curcumin contains an α,β-unsaturated ketone, a reactive chemical substituent that is responsible for its repression of NF-κB. In compounds other than curcumin this same electrophilic moiety is associated with inactivation of the tumor suppressor, p53. Here we report that curcumin behaves analogously to these compounds. It disrupts the conformation of the p53 protein required for its serine phosphorylation, its binding to DNA, its transactivation of p53-responsive genes and p53-mediated cell cycle arrest.

Keywords: IR, ionizing radiation; UV, ultraviolet radiation

Journal Article.  5424 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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