Journal Article

Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors

Manabu Nishikawa, BaoJun Chang and Masayasu Inoue

in Carcinogenesis

Volume 25, issue 11, pages 2101-2105
Published in print November 2004 | ISSN: 0143-3334
Published online November 2004 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgh218
Inducible NO synthase inhibits the growth of free tumor cells, but enhances the growth of solid tumors

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To elucidate the role of nitric oxide (NO) in tumor cell growth in vivo, dynamic aspects of the growth of Ehrlich ascites tumor cells (EATCs) were studied in wild-type (WT) mice and in an inducible strain of NO synthase (iNOS)-deficient (iNOS−/−) mice. Kinetic analysis showed that the rate of free tumor cell growth in the peritoneal cavity was significantly higher in the iNOS−/− mice than in the WT mice. In contrast, EATCs inoculated subcutaneously rapidly grew and formed a solid tumor in WT mice, but failed to grow in iNOS−/− mice. These results clearly indicate that NO generated by iNOS predominantly inhibits the growth of tumor cells in their free form, but enhances the growth of solid tumors.

Keywords: EATC, Ehrlich ascites tumor cell; iNOS, inducible type of NO synthase; iNOS−/−, iNOS deficiency; NO, nitric oxide; VEGF, vascular endothelial growth factor; WT, wild-type

Journal Article.  3491 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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