Journal Article

BC200 RNA in invasive and preinvasive breast cancer

Anna Iacoangeli, Yuan Lin, Eric J. Morley, Ilham A. Muslimov, Riccardo Bianchi, James Reilly, Jeremy Weedon, Raihanatou Diallo, Werner Böcker and Henri Tiedge

in Carcinogenesis

Volume 25, issue 11, pages 2125-2133
Published in print November 2004 | ISSN: 0143-3334
Published online November 2004 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgh228
BC200 RNA in invasive and preinvasive breast cancer

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BC200 RNA, a small functional RNA that operates as a translational modulator, has been implicated in the regulation of local synaptodendritic protein synthesis in neurons. Cell type-specific expression of BC200 RNA is tightly controlled such that the RNA is not normally detected in somatic cells other than neurons. However, the neuron-specific control of BC200 expression is deregulated in a number of tumors. We here report that BC200 RNA is expressed at high levels in invasive carcinomas of the breast. In normal breast tissue or in benign tumors such as fibroadenomas, in contrast, we found that the RNA is not detectable at significant levels. The difference in expression levels between invasive carcinomas and normal/benign tissue was statistically highly significant. Receiver Operating Characteristics analysis of sensitivity and specificity confirmed the diagnostic power of BC200 RNA as a molecular marker of invasive breast cancer. In ductal carcinomas in situ, furthermore, significant BC200 expression was associated with high nuclear grade, suggesting that the presence of BC200 RNA in such tumors may be used as a prognostic indicator of tumor progression. The combined results demonstrate the potential of BC200 expression to serve as a molecular tool in the diagnosis and/or prognosis of breast cancer.

Keywords: AUC, area under the curve; DCIS, ductal carcinomas in situ; HG, high grade; IBCs, invasive breast carcinomas; IDCs, invasive ductal carcinomas; PSA, prostate-specific antigen; NHG, non-high grade; ROC, receiver operating characteristics; ROIs, regions of interest; RSI, relative signal intensity; SUNY HSCB, State University of New York Health Science Center at Brooklyn

Journal Article.  4126 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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