Journal Article

<i>NQO1</i> T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study

C.H. Bock, A.S. Wenzlaff, M.L. Cote, S.J. Land and A.G. Schwartz

in Carcinogenesis

Volume 26, issue 2, pages 381-386
Published in print February 2005 | ISSN: 0143-3334
Published online February 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgh314
NQO1 T allele associated with decreased risk of later age at diagnosis lung cancer among never smokers: results from a population-based study

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The NAD(P)H:quinone oxidoreductase 1 gene, NQO1, contains a C to T transition at amino acid codon 187, which results in very low enzymatic activity. Previous studies of the association between NQO1 genotype and lung cancer have had mixed findings. This population-based case control study examines the association between NQO1 genotype and lung cancer in the largest sample of never smokers (<100 cigarettes, lifetime) to date. Cases (n = 161) were identified through the metropolitan Detroit Surveillance, Epidemiology and End Results (SEER) program, and 5-year age- and race-matched population-based controls (n = 173) were identified using random digit dialing. Allele frequencies of C and T, respectively, were 0.79 and 0.21 in Caucasians, and 0.84 and 0.16 in African Americans. Among those diagnosed aged ≥50 years, C/T and T/T genotyped individuals had 0.48 times lower lung cancer risk than individuals with C/C genotype (95% CI: 0.27–0.87). There was a non-significant suggestion of a protective effect associated with the T allele among those with a history of environmental tobacco smoke exposure (OR = 0.57, 95% CI: 0.32–1.03) but not among those without (OR = 0.98, 95% CI: 0.41–2.38). Sex, race, family history of lung cancer and histologic type did not modify the effect of NQO1 genotype on lung cancer risk. The observed risk reductions may be attributable to the greatly reduced procarcinogen activating of NAD(P)H:quinone oxidoreductase 1 in individuals with at least one copy of the T allele.

Keywords: ETS, environmental tobacco smoke

Journal Article.  4871 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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