Journal Article

Comparative functional genomics for identifying models of human cancer

Ju-Seog Lee, Joe W. Grisham and Snorri S. Thorgeirsson

in Carcinogenesis

Volume 26, issue 6, pages 1013-1020
Published in print June 2005 | ISSN: 0143-3334
Published online January 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi030
Comparative functional genomics for identifying models of human cancer

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  • Clinical Cytogenetics and Molecular Genetics

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Genetically modified mice with overexpressed and/or deleted genes have been used extensively to model human cancer. However, it is uncertain as to what extent the mouse models reproduce the corresponding cancers in humans. We have compared the global gene expression patterns in human and mouse hepatocellular carcinomas (HCCs) in an attempt to identify the mouse models that most extensively reproduce the molecular pathways in the human tumors. The comparative analysis of the gene expression patterns in murine and human HCC indicates that certain genetic mouse models closely reproduce the gene expression patterns of HCC in humans, while others do not. Identification of mouse models that reproduce the molecular features of specific human cancers (or subclasses of specific human cancers) promises to accelerate both the understanding of the molecular pathogenesis of cancer and the discovery of therapeutic targets. We propose that this method, comparative functional genomics, could be effectively applied to the analysis of mouse models for other human cancers.

Keywords: DENA, diethylnitrosamine; HCCs, hepatocellular carcinomas

Journal Article.  4955 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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