Journal Article

Periostin induction in tumor cell line explants and inhibition of <i>in vitro</i> cell growth by anti-periostin antibodies

Isabella T. Tai, Meiru Dai and Lan Bo Chen

in Carcinogenesis

Volume 26, issue 5, pages 908-915
Published in print May 2005 | ISSN: 0143-3334
Published online February 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi034
Periostin induction in tumor cell line explants and inhibition of in vitro cell growth by anti-periostin antibodies

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  • Clinical Cytogenetics and Molecular Genetics

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Several factors have been shown to promote the growth of colorectal cancers. Here, we provide evidence that periostin, a protein with structural and sequence homology with a TGF-β-inducible gene, βig-h3, is upregulated in colorectal cancers and their liver metastasis, and it may play a role in promoting growth in these tumors. In vitro studies reveal that periostin promotes growth and cell proliferation in colorectal cancers and that this effect can be abrogated with antibodies to periostin. Furthermore, exposure of colorectal cancer cells to anti-periostin antibodies activates apoptosis and potentiates the effects of 5-fluorouracil chemotherapy. The results demonstrate the growth-promoting properties of periostin, and a possible role of targeting this protein as a therapeutic option in colorectal cancers.

Keywords: APC, adenomatous polyposis coli; 5-FU, 5-fluorouracil; HNSCC, head and neck squamous cell cancer; mAb, monoclonal antibody

Journal Article.  4629 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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