Journal Article

Complicating the complexity of p53

Karen S. Yee and Karen H. Vousden

in Carcinogenesis

Volume 26, issue 8, pages 1317-1322
Published in print August 2005 | ISSN: 0143-3334
Published online May 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi122
Complicating the complexity of p53

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Recent studies have suggested that the straightforward role of p53 as a transcription factor that functions by inducing apoptotic target genes to eliminate developing tumor cells is only part of a much more complicated story. There is now a firm body of evidence supporting a transcriptionally independent activity of p53 as a functional, if not structural, homologue of the BH3-only proteins. Although this information adds another nuance to the mechanism by which p53 can induce apoptosis, further studies indicate that the apoptotic function of p53 represents only a part of its tumor suppressive activity. Although complicating our understanding of p53, these new insights may also provide some exciting new targets for the design of therapeutics that can reactivate p53 in cancers.

Journal Article.  5004 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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