Journal Article

Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case–control study

Amanda J. Cross, Mary H. Ward, MaryJean Schenk, Martin Kulldorff, Wendy Cozen, Scott Davis, Joanne S. Colt, Patricia Hartge, James R. Cerhan and Rashmi Sinha

in Carcinogenesis

Volume 27, issue 2, pages 293-297
Published in print February 2006 | ISSN: 0143-3334
Published online August 2005 | e-ISSN: 1460-2180 | DOI:
Meat and meat-mutagen intake and risk of non-Hodgkin lymphoma: results from a NCI-SEER case–control study

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Non-Hodgkin Lymphoma (NHL) incidence has risen dramatically over past decades, but the reasons for most of this increase are not known. Meat cooked well-done using high-temperature cooking techniques produces heterocyclic amines (HCAs) and polycyclic aromatic hydrocarbons (PAHs) such as benzo[a]pyrene (B[a]P). This study was conducted as a population-based case–control study in Iowa, Detroit, Seattle and Los Angeles and was designed to determine whether meat, meat-cooking methods, HCAs or PAHs from meat were associated with NHL risk. This study consisted of 458 NHL cases, diagnosed between 1998 and 2000, and 383 controls. Participants completed a 117-item food frequency questionnaire (FFQ), with graphical aids to assess the meat-cooking method and doneness level, which was linked to a HCA and B[a]P database. Logistic regression, comparing the fourth to the first quartile, found no association between red meat or processed meat intake and risk for NHL [odds ratio (OR) and 95% confidence interval (CI): 1.10 (0.67–1.81) and 1.18 (0.74–1.89), respectively]. A marginally significant elevated risk for NHL was associated with broiled meat [OR and 95% CI: 1.32 (0.99–1.77); P trend = 0.09], comparing those who consumed broiled meat with those who did not. The degree to which meat was cooked was not associated with the risk for NHL, although one of the HCAs, DiMeIQx (2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline), was associated with an inverse risk. Fat intake was associated with a significantly elevated risk for NHL [OR and 95% CI: 1.60 (1.05–2.45); P trend = 0.12]; in contrast, animal protein was inversely associated with risk for NHL [OR and 95% CI: 0.39 (0.22–0.70); P trend = 0.004]. Overall, our study suggests that consumption of meat, whether or not it is well-done, does not increase the risk of NHL. Furthermore, neither HCAs nor B[a]P from meat increase the risk of NHL.

Keywords: B[a]P, benzo[a]pyrene; CI, confidence interval; DiMeIQx, 2-amino-3,4,8-trimethylimidazo[4,5-f]quinoxaline; FFQ, food frequency questionnaire; HCAs, heterocyclic amines; OR, odds ratio; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; NHL, non-Hodgkin lymphoma; PAHs, polycyclic aromatic hydrocarbons; PhIP, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine; SEER, Surveillance Epidemiology and End Results

Journal Article.  4183 words. 

Subjects: Clinical Cytogenetics and Molecular Genetics

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