Journal Article

Emerging role of KLF4 in human gastrointestinal cancer

Daoyan Wei, Masashi Kanai, Suyun Huang and Keping Xie

in Carcinogenesis

Volume 27, issue 1, pages 23-31
Published in print January 2005 | ISSN: 0143-3334
Published online October 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi243
Emerging role of KLF4 in human gastrointestinal cancer

More Like This

Show all results sharing this subject:

  • Clinical Cytogenetics and Molecular Genetics

GO

Show Summary Details

Preview

Recent analyses revealed that Krüppel-like factors (KLFs) play important roles in both normal development and carcinogenesis. Of the 16 known KLFs, KLF4 has been shown to be involved in the regulation of proliferation, differentiation and tumorigenesis of gastrointestinal tract epithelium. Clinical, experimental and mechanistic findings indicate that KLF4 is a bona fide tumor suppressor for both gastric and colorectal cancers. In this review, we summarize how this growing area of research has formed and the challenging new frontiers for better understanding of the oncogenic potential of the KLFs.

Keywords: BTE, basic transcription element; CRC, colorectal cancer; GI, gastrointestinal; HDAC, histone deacetylase; KLF, Krüppel-like factor; LOH, Loss of heterozygosity; ODC, ornithine decarboxylase; PanIN, pancreatic intraepithelial neoplasia

Journal Article.  8582 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

Full text: subscription required

How to subscribe Recommend to my Librarian

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.