Journal Article

Experimental models of human bladder carcinogenesis

R.A. Crallan, N.T. Georgopoulos and J. Southgate

in Carcinogenesis

Volume 27, issue 3, pages 374-381
Published in print March 2006 | ISSN: 0143-3334
Published online November 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi266
Experimental models of human bladder carcinogenesis

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Bladder cancer is the fifth most common cancer in the UK, yet human bladder carcinogenesis remains poorly understood and the response of bladder tumours to radio- and chemo-therapy is unpredictable. The aims of this article are to review human bladder carcinogenesis and appraise the different in vitro and in vivo approaches that have been developed to study the process. The review considers how in vitro models based on normal human urothelial (NHU) cells can be applied to human bladder cancer research. We conclude that recent advances in NHU cell culture offer novel approaches for defining urothelial tissue-specific responses to genotoxic and non-genotoxic carcinogens and elucidating the role of specific genes involved in the mechanisms of bladder carcinogenesis and malignant progression.

Keywords: 4-ABP, 4-aminobiphenyl; HPV, human papillomavirus; NHU, normal human urothelial; MMC, mitomycin c; MNU, N-methyl-N-nitrosourea; RNAi, RNA interference; UCC, urothelial cell carcinoma

Journal Article.  7389 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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