Journal Article

<i>N</i>-acetylcysteine and <i>S</i>-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage

Motome Nishikawa-Ogawa, Hideki Wanibuchi, Keiichirou Morimura, Anna Kinoshita, Takayuki Nishikawa, Shuji Hayashi, Yoshihisa Yano and Shoji Fukushima

in Carcinogenesis

Volume 27, issue 5, pages 982-988
Published in print May 2006 | ISSN: 0143-3334
Published online December 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi277

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N-acetylcysteine (NAC) and S-methylcysteine (SMC), water soluble organosulfur compounds contained in garlic, were evaluated for chemoprevention of hepatocarcinogenesis after 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) initiation in rats. Intergastric treatment with NAC or SMC five times a week resulted in decreased numbers and areas of preneoplastic, glutathione S-transferase placental form (GST-P) positive foci of the liver in a dose-dependent manner. Moreover, cell proliferation was reduced in GST-P positive foci by NAC and SMC. Insulin-like growth factor I (IGF-I) and inducible nitric oxide synthase (iNOS) mRNA expressions were found downregulated in the liver by NAC. The studies indicate that NAC can serve as a chemopreventive agent for rat hepatocarcinogenesis induced by MeIQx by reducing cell proliferation, which may involve IGF-I and iNOS downregulation.

Keywords: NAC, N-acetylcysteine; SMC, S-methylcysteine; MeIQx, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline; GST-P, glutathione S-transferase placental form; IGF-I, insulin-like growth factor I; iNOS, inducible nitric oxide synthase; OSC, organosulfur compound; 8-OHdG, 8-hydroxy-2′-deoxyguanosine; AgNORs, silver-stained for nucleolar organizer regions; IGFBP-3, insulin-like growth factor binding protein 3; GAPDH, glyceraldehyde-3-P dehydrogenase; GH, growth hormone

Journal Article.  4553 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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