Journal Article

Inhibition of CWR22Rν1 tumor growth and PSA secretion in athymic nude mice by green and black teas

Imtiaz A. Siddiqui, Najia Zaman, Moammir H. Aziz, Shannon R. Reagan-Shaw, Sami Sarfaraz, Vaqar M. Adhami, Nihal Ahmad, Sheikh Raisuddin and Hasan Mukhtar

in Carcinogenesis

Volume 27, issue 4, pages 833-839
Published in print April 2006 | ISSN: 0143-3334
Published online December 2005 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi323
Inhibition of CWR22Rν1 tumor growth and PSA secretion in athymic nude mice by green and black teas

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Cancer of the prostate gland (CaP), the most common invasive malignancy and a major cause of cancer related deaths in male population in the USA, is an ideal candidate disease for chemoprevention because it is typically detected in elderly population with a relatively slower rate of growth and progression. Many dietary phytochemicals are showing promising chemopreventive effects, at-least in pre-clinical models of CaP. Our published data in cell culture and animal studies, supported by the work from other laboratories, as well as epidemiological observations and case–control studies, suggest that polyphenols present in green tea possess CaP chemopreventive and possibly therapeutic effects. This present study was designed to compare CaP cancer chemopreventive effects of green tea polyphenols (GTP), water extract of black tea, and their major constituents epigallocatechin-3-gallate and theaflavins, respectively, in athymic nude mice implanted with androgen-sensitive human CaP CWR22Rν1 cells. Our data demonstrated that the treatment with all the tea ingredients resulted in (i) significant inhibition in growth of implanted prostate tumors, (ii) reduction in the level of serum prostate specific antigen, (iii) induction of apoptosis accompanied with upregulation in Bax and decrease in Bcl-2 proteins, and (iv) decrease in the levels of VEGF protein. Furthermore, we also found that GTP (0.01 or 0.05% w/v; given after establishment of CWR22Rν1 tumor) causes a significant regression of tumors suggesting therapeutic effects of GTP at human achievable concentrations.

Keywords: CaP, Cancer of the prostate gland; EGCG, epigallocatechin-3-gallate; GTP, green tea polyphenols; PARP, poly ADP-ribose polymerase; PSA, prostate specific antigen; TF, theaflavins.

Journal Article.  5775 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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