Journal Article

Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

Dae J. Kim, K.Sandeep Prabhu, Frank J. Gonzalez and Jeffrey M. Peters

in Carcinogenesis

Volume 27, issue 5, pages 1105-1112
Published in print May 2006 | ISSN: 0143-3334
Published online January 2006 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgi346
Inhibition of chemically induced skin carcinogenesis by sulindac is independent of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)

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Inhibition of cyclooxygenase-2 (COX2) by non-steroidal anti-inflammatory drugs (NSAID) is known to suppress skin carcinogenesis. It was further suggested that inhibition of COX2-derived prostaglandins by NSAIDs could reduce levels of putative endogenous ligands of peroxisome proliferator-activated receptor-β (PPARβ), and these ligands could potentiate tumorigenesis. However, it is currently unclear whether ligand activation of PPARβ either inhibits or potentiates carcinogenesis. The present studies were designed to examine the mechanism of NSAID-mediated chemoprevention in skin, and, in particular, to determine the role of PPARβ in this process. A two-stage skin carcinogenicity bioassay was performed using wild-type and PPARβ-null mice that were fed either a control diet or one containing 0.32 g sulindac/kg diet. Significant inhibition of chemically induced skin carcinogenesis was observed in both wild-type and PPARβ-null mice, and this was associated with a marked decrease in the concentration of skin prostaglandins including PGE2 and PGI2. Results from these studies demonstrate that inhibition of COX2 by dietary sulindac in mouse skin can effectively inhibit chemically induced skin carcinogenesis, and suggest that the mechanism underlying this chemopreventive effect is independent of PPARβ. Additionally, results from these studies do not support the hypothesis that ligand activation of PPARβ by COX-derived metabolites potentiates chemically induced skin carcinogenesis.

Keywords: COX2, cyclooxygenase-2; DMBA, 7,12 dimethylbenz[a]anthracene; NSAID, non-steroidal anti-inflammatory drugs; PPAR, peroxisome proliferator-activated receptor; TPA, 12-O-tetradecanoylphorbol-13-acetate

Journal Article.  5905 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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