Journal Article

Endogenous versus exogenous exposure to <i>N</i>-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

Paula Jakszyn, Sheila Bingham, Guillem Pera, Antonio Agudo, Robert Luben, Ailsa Welch, Heiner Boeing, Giuseppe del Giudice, Domenico Palli, Calogero Saieva, Vittorio Krogh, Carlotta Sacerdote, Rosario Tumino, Salvatore Panico, Göran Berglund, Henrik Simán, Göran Hallmans, María José Sanchez, Nerea Larrañaga, Aurelio Barricarte, María Dolores Chirlaque, José R. Quirós, Timothy J. Key, Naomi Allen, Eiliv Lund, Fátima Carneiro, Jakob Linseisen, Gabriele Nagel, Kim Overvad, Anne Tjonneland, Anja Olsen, H. Bas Bueno-de-Mesquita, Marga O. Ocké, Petra HM. Peeters, Mattijs E. Numans, Françoise Clavel-Chapelon, Antonia Trichopoulou, Claus Fenger, Roger Stenling, Pietro Ferrari, Mazda Jenab, Teresa Norat, Elio Riboli and Carlos A. Gonzalez

in Carcinogenesis

Volume 27, issue 7, pages 1497-1501
Published in print July 2006 | ISSN: 0143-3334
Published online March 2006 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgl019
Endogenous versus exogenous exposure to N-nitroso compounds and gastric cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC-EURGAST) study

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The risk of gastric cancer (GC) associated with dietary intake of nitrosodimethylamine (NDMA) and endogenous formation of nitroso compounds (NOCs) was investigated in the European Prospective Investigation into Cancer and Nutrition (EPIC). The study included 521 457 individuals and 314 incident cases of GC that had occurred after 6.6 average years of follow-up. An index of endogenous NOC (ENOC) formation was estimated using data of the iron content from meat intake and faecal apparent total NOC formation according to previous published studies. Antibodies to Helicobacter pylori and vitamin C levels were measured in a sub-sample of cases and matched controls included in a nested case–control within the cohort. Exposure to NDMA was <1 μg on average compared with 93 μg on average from ENOC. There was no association between NDMA intake and GC risk (HR, 1.00; 95% CI, 0.7–1.43). ENOC was significantly associated with non-cardia cancer risk (HR, 1.42; 95% CI, 1.14–1.78 for an increase of 40 μg/day) but not with cardia cancer (HR, 0.96; 95% CI, 0.69–1.33). Although the number of not infected cases is low, our data suggest a possible interaction between ENOC and H.pylori infection (P for interaction = 0.09). Moreover, we observed an interaction between plasma vitamin C and ENOC (P < 0.02). ENOC formation may account for our previously reported association between red and processed meat consumption and gastric cancer risk.

Keywords: ATNC, apparent total NOCs; ENOC, endogenous NOC; EPIC, European Prospective Investigation into Cancer and Nutrition; GC, gastric cancer; HR, hazard ratio; NDMA, nitrosodimethylamine; NOCs, N-nitroso compounds

Journal Article.  3650 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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