Journal Article

Negative energy balance induced by voluntary wheel running inhibits polyp development in APC<sup>Min</sup> mice

Lisa H. Colbert, Volker Mai, Janet A. Tooze, Susan N. Perkins, David Berrigan and Stephen D. Hursting

in Carcinogenesis

Volume 27, issue 10, pages 2103-2107
ISSN: 0143-3334
Published online May 2006 | e-ISSN: 1460-2180 | DOI: http://dx.doi.org/10.1093/carcin/bgl056
Negative energy balance induced by voluntary wheel running inhibits polyp development in APCMin mice

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Treadmill running of ∼0.9 km/day has had inconsistent effects on spontaneous intestinal polyp development in C57BL/6J-ApcMin/J (Min) mice; the amount of energy expenditure and/or a lack of hormonal changes could account for this variability. The purpose of this study was to examine the effects of a negative energy balance induced by voluntary wheel running on polyps, insulin-like growth factor-1 (IGF-1) and corticosterone in Min mice. Seven-week-old male Min mice were randomly assigned to control (CON, n = 23) or wheel running (EX, n = 24) conditions for a 10-week study period. All mice had water and AIN-76A diet ad libitum for the first ∼3 weeks on study, after which the EX group was pair-fed to the CON group to maintain a negative energy balance due to the exercise. EX mice voluntarily ran 3.8 km/day (2.7–6.0 km/day) (median, interquartile range) and weighed less than CON mice throughout the study. More CON mice died before the end of the study versus EX mice (26 versus 0%, P < 0.01). CON mice had significantly more polyps versus EX mice (21.6 ± 1.5 versus 16.9 ± 2.0, P < 0.01; mean ± SE), and daily running distance in EX was inversely correlated with total polyp number (r = −0.70, P < 0.01). Urinary corticosterone output (P < 0.01) and serum IGF-1 were significantly higher in EX than CON (P < 0.001); however, total polyp number was unrelated to corticosterone (r = 0.05, P = 0.84) and IGF-1 (r = −0.01, P = 0.93). In this study, a negative energy balance produced by wheel running exercise and restricted feeding decreased polyp burden in male Min mice and appeared to have a dose–response effect on polyp number. Although EX affected IGF-1 and corticosterone, neither marker was related to total polyp number.

Journal Article.  4553 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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