Journal Article

Association of polymorphisms in the <i>MTH1</i> gene with small cell lung carcinoma risk

Takashi Kohno, Tokuki Sakiyama, Hideo Kunitoh, Koichi Goto, Yutaka Nishiwaki, Daizo Saito, Hiroshi Hirose, Takashi Eguchi, Noriko Yanagitani, Ryusei Saito, Rumie Sasaki-Matsumura, Sachiyo Mimaki, Kaoru Toyama, Seiichiro Yamamoto, Aya Kuchiba, Tomotaka Sobue, Tsutomu Ohta, Misao Ohki and Jun Yokota

in Carcinogenesis

Volume 27, issue 12, pages 2448-2454
ISSN: 0143-3334
Published online June 2006 | e-ISSN: 1460-2180 | DOI: https://dx.doi.org/10.1093/carcin/bgl095
Association of polymorphisms in the MTH1 gene with small cell lung carcinoma risk

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Fifty single-nucleotide polymorphisms (SNPs) associated with amino acid changes in 36 genes involved in diverse DNA repair pathways were assessed for associations with risk for small cell lung carcinoma (SCLC) by a case–control study consisting of 211 SCLC cases and 685 controls. An SNP, Val83Met, in the MTH1 (mutT homolog 1) gene encoding a triphosphatase that hydrolyzes pro-mutagenic oxidized nucleoside triphosphates, such as 8-hydroxy-dGTP and 2-hydroxy-dATP, showed the strongest and a significant association with SCLC risk [odds ratio (OR) = 1.6, 95% confidence interval (CI): 1.2–2.2, P = 0.004], while three other SNPs in the TP53, BLM and SNM1 genes, respectively, also showed marginal associations (0.05 < P < 0.1). Another SNP, which causes a nucleotide change in the 5′-UTR of MTH1 transcripts leading to alternative translation initiation, was additionally examined and the SNP also showed a significant association (OR = 1.7, 95% CI: 1.2–2.3, P = 0.002). The two SNPs in the MTH1 gene were in linkage disequilibrium, and the OR for carrying a copy of the haplotype consisting of both the risky SNP alleles was 2.0 (95% CI: 1.2–3.2, P = 0.002). The present results indicate that inter-individual differences in MTH1 activities due to SNPs are involved in susceptibility to SCLC.

Journal Article.  4867 words.  Illustrated.

Subjects: Clinical Cytogenetics and Molecular Genetics

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